Binding profiles of BAN2401 and aducanumab CTAD Dec 7 2019.

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Ser bara positiva nyheter! Smil 19-12-09 15:01
Märklig reaktion på goda resultat balonka 19-12-09 13:52
Binding profiles of BAN2401 and aducanumab CTAD Dec 7 2019. jhmx 19-12-09 12:56
1/1
2019-12-09 15:01 IP: 4LUlhvoT+

Conclusion, BAN2401 vs. aducanumab

•BAN2401 showed 16 - 100 times stronger in vitro binding to Aβ
protofibrils than aducanumab
• BAN2401 was more selective for oligomers and protofibrils as
compared to fibrils
• BAN2401 showed stronger binding to Aβ oligomers
• BAN2401 showed slightly more efficient immunodepletion of brain Aβ
protofibrils
• The stronger binding of BAN2401 to soluble aggregated Aβ species
may mediate the differences in clinical profile observed between the
two antibodies

https://www.bioarctic.se/sv/wp-content/uploads/sites/4/2019/12/binding-profiles-of-ban2401-and-aducanumab-ctad-dec-7-2019.pdf
2019-12-09 13:52 IP: LNxnCv9E1
Kan det tolkas annat än positivt? Kursen borde gå upp men knappt någon handel.
BioArctic / Binding profiles of BAN2401 and aducanumab CTAD Dec 7 2019. / Binding profiles of BAN2401 and aducanumab CTAD Dec 7 2019.
2019-12-09 12:56 IP: CY/YDnoaM
Conclusion, BAN2401 vs. aducanumab

BAN2401 showed 16 - 100 times stronger in vitro binding to Aβ protofibrils than aducanumab.

Allt hittills tyder på att vi kan förvänta oss starka resultat fr Fas III studien (in vivo).

Redigerades 2019-12-09

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